新冠病毒会不会是自然原因引起了定向变异，引发各全球感染？
通过基因组对比分析，新冠病毒不是从实验室里人工操作得到的。病毒起源还是未解之谜，不要相信阴谋论。目前的科学观点是自然选择压力导致spike protein等基因突变，导致跨物种传
通过基因组对比分析，新冠病毒不是从实验室里人工操作得到的。病毒起源还是未解之谜，不要相信阴谋论。目前的科学观点是自然选择压力导致spike protein等基因突变，导致跨物种传播。The evidence shows that SARS-CoV-2 is not a purposefully manipulated virus, it is currently impossible to prove or disprove the other theories of its origin. 有兴趣仔细看看https://www.nature.com/articles/s41591-020-0820-9
1. Natural selection in an animal host before zoonotic transfer
2. Natural selection in humans following zoonotic transfer
3. Selection during passage. The acquisition of both the polybasic cleavage site and predicted O-linked glycans also argues against culture-based scenarios.
In the midst of the global COVID-19 public-health emergency, it is reasonable to wonder why the origins of the pandemic matter. Detailed understanding of how an animal virus jumped species boundaries to infect humans so productively will help in the prevention of future zoonotic events. For example, if SARS-CoV-2 pre-adapted in another animal species, then there is the risk of future re-emergence events. In contrast, if the adaptive process occurred in humans, then even if repeated zoonotic transfers occur, they are unlikely to take off without the same series of mutations. In addition, identifying the closest viral relatives of SARS-CoV-2 circulating in animals will greatly assist studies of viral function. Indeed, the availability of the RaTG13 bat sequence helped reveal key RBD mutations and the polybasic cleavage site.
